Cross-species Comparison of Estrogenic Endocrine Disruptor-induced, Uterotrophic Gene Expression in the Rodent

Cross-species Comparison of Estrogenic Endocrine Disruptor-induced, Uterotrophic Gene Expression in the Rodent

4.11 - 1251 ratings - Source



Estrogenic endocrine disrupting chemicals (EEDCs) are a growing matter of concern in the etiology of several developmental, reproductive and general health related adverse health effects. These include breast cancer, decreasing fertility rates, and birth defects. These chemicals are structurally diverse and arise from a broad range of sources including natural products, pesticides, food processing and packaging materials, and pharmaceuticals. These chemicals mediate most of their effects through estrogen receptors (ERs) which are ligand-dependant transcription factors. Thus the main mechanism of estrogen signaling involves the regulation of expression of target genes. A major consideration in ER signaling is selective estrogen receptor modulator (SERM) activity, which consists of differential activation of the ER depending upon ligand-specific conformational changes and subsequent transcriptional activities of the activated ER. Thus understanding the activity of SERMs is an essential part of our assessment of EEDCs.... was performed where differentially expressed orthologous genes (NCBI, HomoloGene) for each data set were entered into the 4-way Venn Diagram Generator (http://www.pangloss.com/seidel/Protocols/ venn4.cgi). The number and identityanbsp;...


Title:Cross-species Comparison of Estrogenic Endocrine Disruptor-induced, Uterotrophic Gene Expression in the Rodent
Author: Joshua Caleb Kwekel
Publisher:ProQuest - 2008
ISBN-13:

You must register with us as either a Registered User before you can Download this Book. You'll be greeted by a simple sign-up page.

Once you have finished the sign-up process, you will be redirected to your download Book page.

How it works:
  • 1. Register a free 1 month Trial Account.
  • 2. Download as many books as you like (Personal use)
  • 3. Cancel the membership at any time if not satisfied.


Click button below to register and download Ebook
Privacy Policy | Contact | DMCA