OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

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This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...Tissues and the resulting samples (items) should be processed and analysed using a block design, where items from the ... Individual animal data should be presented in tabular form. ... or a clear increase in the mutant frequency in a single dose group compared to the solvent/vehicle control group. ... While biological relevance of the results should be the primary consideration, appropriate statistical methods may be used as an aid in evaluating the test results (4) (14) (16) (27) (28).


Title:OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays
Author: OECD
Publisher:OECD Publishing - 2011-07-28
ISBN-13:

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